Innovation Watch - Latest UM Patents (2026-10-19)
A thermochromic afterglow carbon dot and its preparation method and application [Granted Patent]
一種熱致變色的餘輝碳點及其製備方法和應用 [授權專利]
Publication No.:
CN118620614B
Publication Date:
2026-10-16
Applicant(s):
澳門大學； University of Macau
Inventor(s):
曲松楠；劉鈺鵬； Qu Songnan; Liu Yupeng
Technology Field(s):
基礎材料化學；材料、冶金；微結構與奈米技術； Basic materials chemistry; Materials, metallurgy; Micro-structural and nano-technology
The invention discloses thermochromic afterglow carbon dots, as well as their preparation method and applications. The raw materials used to prepare the afterglow carbon dots comprise a quinolone compound and a solid-state solvent at a mass ratio of 1:(1–300). The afterglow carbon dots of the invention exhibit dual-mode afterglow through phosphorescence and thermally activated delayed fluorescence. They achieve a photoluminescence quantum yield of up to 51% and an afterglow lifetime exceeding 0.3 seconds, making them suitable for various applications, including water-based fluorescent inks, advanced information encryption, and data storage. In addition, the afterglow carbon dots display different afterglow modes and colors at different temperatures, thereby successfully achieving thermochromic afterglow. They can also be printed or applied to paper-based materials to produce dual-mode afterglow, offering a simple and practical application method.
Publication No.:
CN118620614B
Publication Date:
2026-10-16
Applicant(s):
澳門大學； University of Macau
Inventor(s):
曲松楠；劉鈺鵬； Qu Songnan; Liu Yupeng
Technology Field(s):
基礎材料化學；材料、冶金；微結構與奈米技術； Basic materials chemistry; Materials, metallurgy; Micro-structural and nano-technology
The invention discloses thermochromic afterglow carbon dots, as well as their preparation method and applications. The raw materials used to prepare the afterglow carbon dots comprise a quinolone compound and a solid-state solvent at a mass ratio of 1:(1–300). The afterglow carbon dots of the invention exhibit dual-mode afterglow through phosphorescence and thermally activated delayed fluorescence. They achieve a photoluminescence quantum yield of up to 51% and an afterglow lifetime exceeding 0.3 seconds, making them suitable for various applications, including water-based fluorescent inks, advanced information encryption, and data storage. In addition, the afterglow carbon dots display different afterglow modes and colors at different temperatures, thereby successfully achieving thermochromic afterglow. They can also be printed or applied to paper-based materials to produce dual-mode afterglow, offering a simple and practical application method.
A water electrolysis anode and its preparation method and application
一種電解水陽極及其製備方法和應用
Publication No.:
CN122918671A
Publication Date:
2026-10-16
Applicant(s):
澳門大學； University of Macau
Inventor(s):
王雙鵬；張浩；潘暉； Wang Shuangpeng; Zhang Hao; Pan Hui
Technology Field(s):
表面技術、塗層； Surface technology, coating
The invention relates to the field of water electrolysis and specifically discloses an anode for water electrolysis, together with its preparation method and applications. The anode comprises an electrode material and a modification layer supported on the surface of the electrode material. The raw materials used to prepare the modification layer comprise at least one of a carboxyl-containing compound and a metal salt. By providing the modification layer on the surface of the electrode material, the water-electrolysis anode enables interactions between the modification layer and the metal centers on the electrode surface. These interactions fine-tune the electron-cloud density and electronic state of the surface metal atoms and optimize the adsorption free energy of key intermediates in the oxygen evolution reaction, thereby lowering the reaction energy barrier and enhancing electrocatalytic activity. The modification layer acts as a “molecular coating” on the electrode surface. Under the harsh operating conditions of high anodic potentials and strongly alkaline environments, it suppresses excessive surface oxidation, inactive phase transitions, and detrimental reconstruction of the electrode material. This helps preserve the integrity of the catalytically active surface and extends the service life of the water-electrolysis anode.
Publication No.:
CN122918671A
Publication Date:
2026-10-16
Applicant(s):
澳門大學； University of Macau
Inventor(s):
王雙鵬；張浩；潘暉； Wang Shuangpeng; Zhang Hao; Pan Hui
Technology Field(s):
表面技術、塗層； Surface technology, coating
The invention relates to the field of water electrolysis and specifically discloses an anode for water electrolysis, together with its preparation method and applications. The anode comprises an electrode material and a modification layer supported on the surface of the electrode material. The raw materials used to prepare the modification layer comprise at least one of a carboxyl-containing compound and a metal salt. By providing the modification layer on the surface of the electrode material, the water-electrolysis anode enables interactions between the modification layer and the metal centers on the electrode surface. These interactions fine-tune the electron-cloud density and electronic state of the surface metal atoms and optimize the adsorption free energy of key intermediates in the oxygen evolution reaction, thereby lowering the reaction energy barrier and enhancing electrocatalytic activity. The modification layer acts as a “molecular coating” on the electrode surface. Under the harsh operating conditions of high anodic potentials and strongly alkaline environments, it suppresses excessive surface oxidation, inactive phase transitions, and detrimental reconstruction of the electrode material. This helps preserve the integrity of the catalytically active surface and extends the service life of the water-electrolysis anode.
A large-sized high-activity cell ball and its preparation method
一種大尺寸高活性細胞球及其製備方法
Publication No.:
CN122898447A
Publication Date:
2026-10-13
Applicant(s):
澳門大學； University of Macau
Inventor(s):
王春明；黎虎； Wang Chunming; Li Hu
Technology Field(s):
生物技術； Biotechnology
The invention belongs to the field of biomedical engineering and specifically relates to a large, highly viable cell spheroid and a method for its preparation. The method first uses an aqueous two-phase system (ATPS) and osmotic pressure to preassemble cells into microspheroidal modules. Lipid-anchored click-reactive groups are then introduced, and osmotic compression is applied to induce interfacial bioorthogonal reactions between the modules, enabling the rapid construction of millimeter-scale tissues within two hours. The resulting cell spheroids, measuring 200–1,000 µm in diameter, contain more than 90% viable cells, effectively overcoming the diffusion-limited constraints associated with conventional methods for producing large spheroids. qPCR analysis showed that, compared with the 2D culture group, the AML12 assemblies exhibited increases of several tens of fold in the expression of key functional genes, including albumin, CYP1A2, and TDO2. These results demonstrate that the preparation method offers significant advantages in maintaining the biological activity and function of large-scale tissue constructs.
Publication No.:
CN122898447A
Publication Date:
2026-10-13
Applicant(s):
澳門大學； University of Macau
Inventor(s):
王春明；黎虎； Wang Chunming; Li Hu
Technology Field(s):
生物技術； Biotechnology
The invention belongs to the field of biomedical engineering and specifically relates to a large, highly viable cell spheroid and a method for its preparation. The method first uses an aqueous two-phase system (ATPS) and osmotic pressure to preassemble cells into microspheroidal modules. Lipid-anchored click-reactive groups are then introduced, and osmotic compression is applied to induce interfacial bioorthogonal reactions between the modules, enabling the rapid construction of millimeter-scale tissues within two hours. The resulting cell spheroids, measuring 200–1,000 µm in diameter, contain more than 90% viable cells, effectively overcoming the diffusion-limited constraints associated with conventional methods for producing large spheroids. qPCR analysis showed that, compared with the 2D culture group, the AML12 assemblies exhibited increases of several tens of fold in the expression of key functional genes, including albumin, CYP1A2, and TDO2. These results demonstrate that the preparation method offers significant advantages in maintaining the biological activity and function of large-scale tissue constructs.
A cross-city low-altitude route planning method for electric vertical take-off and landing aircraft
一種電動垂直起降飛行器的跨城低空航線規劃方法
Publication No.:
CN122905268A
Publication Date:
2026-10-13
Applicant(s):
橫琴粵澳深度合作區澳門大學高等研究院（橫琴澳門大學高等研究院）；珠海澳大科技研究院； University of Macau Advanced Research Institute in Hengqin (HUMRI); Zhuhai UM Science & Technology Research Institute (ZUMRI)
Inventor(s):
惠紅勳；李一堂； Hui Hongxun; Li Yitang
Technology Field(s):
資訊科技管理方法；控制； IT methods for management; Control
The invention belongs to the fields of transportation and airspace management and discloses a method for planning intercity low-altitude routes for electric vertical take-off and landing (eVTOL) aircraft. Based on the operational characteristics of eVTOL aircraft and transportation demand between urban agglomerations, the method establishes a route-planning framework comprising four dimensions: demand analysis, geographical constraints, infrastructure compatibility, and policy coordination. The method covers four typical application scenarios: interprovincial routes, intraprovincial routes, overwater routes, and tourism routes. Candidate routes are evaluated and prioritized based on travel distance and time savings. The method can effectively alleviate congestion in ground transportation and improve regional coordination efficiency. It also offers the advantages of rapid deployment, environmental friendliness, and high economic value, making it suitable for the initial planning and expansion of low-altitude route networks during the early stage of eVTOL commercialization. The invention can be widely applied to the development of the low-altitude economy in urban agglomerations, electric aircraft transportation network planning, and smart-city transportation system design.
Publication No.:
CN122905268A
Publication Date:
2026-10-13
Applicant(s):
橫琴粵澳深度合作區澳門大學高等研究院（橫琴澳門大學高等研究院）；珠海澳大科技研究院； University of Macau Advanced Research Institute in Hengqin (HUMRI); Zhuhai UM Science & Technology Research Institute (ZUMRI)
Inventor(s):
惠紅勳；李一堂； Hui Hongxun; Li Yitang
Technology Field(s):
資訊科技管理方法；控制； IT methods for management; Control
The invention belongs to the fields of transportation and airspace management and discloses a method for planning intercity low-altitude routes for electric vertical take-off and landing (eVTOL) aircraft. Based on the operational characteristics of eVTOL aircraft and transportation demand between urban agglomerations, the method establishes a route-planning framework comprising four dimensions: demand analysis, geographical constraints, infrastructure compatibility, and policy coordination. The method covers four typical application scenarios: interprovincial routes, intraprovincial routes, overwater routes, and tourism routes. Candidate routes are evaluated and prioritized based on travel distance and time savings. The method can effectively alleviate congestion in ground transportation and improve regional coordination efficiency. It also offers the advantages of rapid deployment, environmental friendliness, and high economic value, making it suitable for the initial planning and expansion of low-altitude route networks during the early stage of eVTOL commercialization. The invention can be widely applied to the development of the low-altitude economy in urban agglomerations, electric aircraft transportation network planning, and smart-city transportation system design.
IONIZABLE LIPID, SCREENING METHOD THEREFOR AND APPLICATION THEREOF
可電離脂質及其篩選方法與應用
Publication No.:
WO2025227452A9
Publication Date:
2026-10-08
Applicant(s):
復旦大學；澳門大學； Fudan University; University of Macau
Inventor(s):
歐陽德方；王維；林金鐘； Ouyang, Defang; Wang, Wei; Lin, Jinzhong
Technology Field(s):
電腦技術； Computer technology
The invention provides ionizable lipids, as well as methods for their screening and applications. By integrating computational modeling algorithms, the method enables prediction of the molecular structures of ionizable lipids and key properties such as in vivo mRNA delivery efficiency and apparent pKa, thereby facilitating formulation screening for mRNA-loaded lipid nanoparticles. A physiologically based pharmacokinetic (PBPK) model was also developed to calculate the rate constants of key steps in the pharmacokinetics of lipid nanoparticles. The disclosed methods and models provide guidance for the research and development of lipid nanoparticles and support the rapid development of mRNA-LNP therapeutics. Using the model-based simulation approach, multiple novel ionizable lipids suitable for mRNA-LNP delivery systems can be identified, and their high delivery efficiency has been experimentally validated.
Publication No.:
WO2025227452A9
Publication Date:
2026-10-08
Applicant(s):
復旦大學；澳門大學； Fudan University; University of Macau
Inventor(s):
歐陽德方；王維；林金鐘； Ouyang, Defang; Wang, Wei; Lin, Jinzhong
Technology Field(s):
電腦技術； Computer technology
The invention provides ionizable lipids, as well as methods for their screening and applications. By integrating computational modeling algorithms, the method enables prediction of the molecular structures of ionizable lipids and key properties such as in vivo mRNA delivery efficiency and apparent pKa, thereby facilitating formulation screening for mRNA-loaded lipid nanoparticles. A physiologically based pharmacokinetic (PBPK) model was also developed to calculate the rate constants of key steps in the pharmacokinetics of lipid nanoparticles. The disclosed methods and models provide guidance for the research and development of lipid nanoparticles and support the rapid development of mRNA-LNP therapeutics. Using the model-based simulation approach, multiple novel ionizable lipids suitable for mRNA-LNP delivery systems can be identified, and their high delivery efficiency has been experimentally validated.