Innovation Watch - Latest UM Patents (2026-07-20)
Use of spheroidal material in preparation of intravenous injection [Granted Patent]
球體物質在製備靜脈注射劑中的應用 [授權專利]
Publication No.:
CN115590883B
Publication Date:
2026-07-20
Applicant(s):
澳門大學；雲南中科靈長類生物醫學重點實驗室; University of Macau; Yunnan Zhongke Primates Biomedical Key Laboratory
Inventor(s):
徐仁和；司維；楊昌坤；李恩琴；嚴亞萍; Xu Renhe; Si Wei; Yang Changkun; Li Enqin; Yan Yaping
Technology Field(s):
生物技術、製藥; Biotechnology, Pharmaceuticals
The present invention discloses the use of spheroidal substances in the preparation of intravenous formulations, relating to the field of biomedicine. The invention provides intravenous administration of MSC spheroids or spheroidal substances formed from biomaterials as a novel in vivo delivery approach. Compared with intravenous administration of dispersed MSCs, intravenous administration of MSC spheroids reduces pulmonary retention of MSCs and prolongs their residence time and viability in the bloodstream and peripheral tissues, thereby potentially improving therapeutic efficacy for autoimmune diseases, inflammatory diseases, and tissue or organ injuries. In addition, intravenous administration of biomaterial spheroids is safe. Such spheroids can carry drugs, bioactive molecules, or detection molecules for the diagnosis and treatment of animal disease models or patients. Compared with monomeric molecules, they are more effective and longer-lasting, and can also carry multiple molecules to produce synergistic effects. Accordingly, the present invention provides a novel route of use and research method for the clinical application of cells and biomaterials.
Publication No.:
CN115590883B
Publication Date:
2026-07-20
Applicant(s):
澳門大學；雲南中科靈長類生物醫學重點實驗室; University of Macau; Yunnan Zhongke Primates Biomedical Key Laboratory
Inventor(s):
徐仁和；司維；楊昌坤；李恩琴；嚴亞萍; Xu Renhe; Si Wei; Yang Changkun; Li Enqin; Yan Yaping
Technology Field(s):
生物技術、製藥; Biotechnology, Pharmaceuticals
The present invention discloses the use of spheroidal substances in the preparation of intravenous formulations, relating to the field of biomedicine. The invention provides intravenous administration of MSC spheroids or spheroidal substances formed from biomaterials as a novel in vivo delivery approach. Compared with intravenous administration of dispersed MSCs, intravenous administration of MSC spheroids reduces pulmonary retention of MSCs and prolongs their residence time and viability in the bloodstream and peripheral tissues, thereby potentially improving therapeutic efficacy for autoimmune diseases, inflammatory diseases, and tissue or organ injuries. In addition, intravenous administration of biomaterial spheroids is safe. Such spheroids can carry drugs, bioactive molecules, or detection molecules for the diagnosis and treatment of animal disease models or patients. Compared with monomeric molecules, they are more effective and longer-lasting, and can also carry multiple molecules to produce synergistic effects. Accordingly, the present invention provides a novel route of use and research method for the clinical application of cells and biomaterials.
An optimal scheduling method for power data element resources considering data value differences
一種考慮資料價值差異的電力資料要素資源最佳化排程方法
Publication No.:
CN122414492A
Publication Date:
2026-07-20
Applicant(s):
珠海澳大科技研究院；國網江蘇省電力有限公司電力科學研究院；橫琴粵澳深度合作區澳門大學高等研究院（橫琴澳門大學高等研究院）; Zhuhai UM Science & Technology Research Institute (ZUMRI); State Grid Jiangsu Electric Power Co., Ltd. Electric Power Research Institute; University of Macau Advanced Research Institute in Hengqin (HUMRI)
Inventor(s):
惠紅勳；陳燁；馬麗雅；宋永華; Hui Hongxun; Chen Ye; Ma Liya; Song Yonghua
Technology Field(s):
資訊科技管理方法、電腦技術; IT methods for management, Computer technology
The present invention relates to the field of data trading, and discloses a power data element resource optimal scheduling method that accounts for differences in data value. The method includes establishing a data element characteristic evaluation model and a comprehensive data resource value evaluation model for power data element resource aggregators, and, for power data element resource aggregators with differentiated data values, establishing a resource aggregation optimal scheduling model for a data center. In certain embodiments of the invention, the scheduling method can effectively encourage data aggregators to participate in the data center’s resource scheduling. On the one hand, the data center designs resource scheduling instructions for data aggregators with different data element values, thereby scheduling a greater amount of data element resources with high data value. On the other hand, by enabling data aggregators to obtain differentiated utilities, data aggregators with high data value are more willing to accept the resource scheduling of the data center.
Publication No.:
CN122414492A
Publication Date:
2026-07-20
Applicant(s):
珠海澳大科技研究院；國網江蘇省電力有限公司電力科學研究院；橫琴粵澳深度合作區澳門大學高等研究院（橫琴澳門大學高等研究院）; Zhuhai UM Science & Technology Research Institute (ZUMRI); State Grid Jiangsu Electric Power Co., Ltd. Electric Power Research Institute; University of Macau Advanced Research Institute in Hengqin (HUMRI)
Inventor(s):
惠紅勳；陳燁；馬麗雅；宋永華; Hui Hongxun; Chen Ye; Ma Liya; Song Yonghua
Technology Field(s):
資訊科技管理方法、電腦技術; IT methods for management, Computer technology
The present invention relates to the field of data trading, and discloses a power data element resource optimal scheduling method that accounts for differences in data value. The method includes establishing a data element characteristic evaluation model and a comprehensive data resource value evaluation model for power data element resource aggregators, and, for power data element resource aggregators with differentiated data values, establishing a resource aggregation optimal scheduling model for a data center. In certain embodiments of the invention, the scheduling method can effectively encourage data aggregators to participate in the data center’s resource scheduling. On the one hand, the data center designs resource scheduling instructions for data aggregators with different data element values, thereby scheduling a greater amount of data element resources with high data value. On the other hand, by enabling data aggregators to obtain differentiated utilities, data aggregators with high data value are more willing to accept the resource scheduling of the data center.
A power distribution system planning method for dealing with seasonal imbalance of heat waves and strengthening year by year
一種應對熱浪季節性失衡與逐年強化的配電系統規劃方法
Publication No.:
CN122414759A
Publication Date:
2026-07-20
Applicant(s):
珠海澳大科技研究院；國網江蘇省電力有限公司電力科學研究院；橫琴粵澳深度合作區澳門大學高等研究院（橫琴澳門大學高等研究院）; Zhuhai UM Science & Technology Research Institute (ZUMRI); State Grid Jiangsu Electric Power Co., Ltd. Electric Power Research Institute; University of Macau Advanced Research Institute in Hengqin (HUMRI)
Inventor(s):
惠紅勳；張振威；陳燁；宋永華; Hui Hongxun; Zhang Zhenwei; Chen Ye; Song Yonghua
Technology Field(s):
資訊科技管理方法、電腦技術、電機、設備、能源; IT methods for management, Computer technology, Electrical machinery, apparatus, energy
This invention discloses a distribution system planning method for addressing the seasonal imbalance and year‑on‑year intensification of heatwaves, and belongs to the field of power system planning and operation optimization. The method first collects multi‑year hourly meteorological data for a target city together with basic distribution system data, and generates multi‑time‑scale heatwave meteorological trajectories that capture both short‑term seasonal fluctuations and long‑term intensification trends. It then uses a source‑load meteorological sensitivity mapping to convert meteorological variables into a building cooling load amplification factor and a green power output correction factor, thereby obtaining the net nodal injection power. A heatwave source‑load imbalance risk index is calculated and used to screen critical heatwave scenarios, on the basis of which a nodal net injection power envelope and a heatwave disturbance budget are constructed to form a compact composite uncertainty set. A progressive two‑stage robust planning model is then established and solved. The invention reduces the computational complexity associated with high‑dimensional heatwave scenarios and improves the planning adaptability, operational security, and engineering feasibility of urban distribution systems under heatwave conditions.
Publication No.:
CN122414759A
Publication Date:
2026-07-20
Applicant(s):
珠海澳大科技研究院；國網江蘇省電力有限公司電力科學研究院；橫琴粵澳深度合作區澳門大學高等研究院（橫琴澳門大學高等研究院）; Zhuhai UM Science & Technology Research Institute (ZUMRI); State Grid Jiangsu Electric Power Co., Ltd. Electric Power Research Institute; University of Macau Advanced Research Institute in Hengqin (HUMRI)
Inventor(s):
惠紅勳；張振威；陳燁；宋永華; Hui Hongxun; Zhang Zhenwei; Chen Ye; Song Yonghua
Technology Field(s):
資訊科技管理方法、電腦技術、電機、設備、能源; IT methods for management, Computer technology, Electrical machinery, apparatus, energy
This invention discloses a distribution system planning method for addressing the seasonal imbalance and year‑on‑year intensification of heatwaves, and belongs to the field of power system planning and operation optimization. The method first collects multi‑year hourly meteorological data for a target city together with basic distribution system data, and generates multi‑time‑scale heatwave meteorological trajectories that capture both short‑term seasonal fluctuations and long‑term intensification trends. It then uses a source‑load meteorological sensitivity mapping to convert meteorological variables into a building cooling load amplification factor and a green power output correction factor, thereby obtaining the net nodal injection power. A heatwave source‑load imbalance risk index is calculated and used to screen critical heatwave scenarios, on the basis of which a nodal net injection power envelope and a heatwave disturbance budget are constructed to form a compact composite uncertainty set. A progressive two‑stage robust planning model is then established and solved. The invention reduces the computational complexity associated with high‑dimensional heatwave scenarios and improves the planning adaptability, operational security, and engineering feasibility of urban distribution systems under heatwave conditions.
A temperature-compensated quartz crystal oscillator and its implementation method
一種溫度補償石英晶體振盪器及其實現方法
Publication No.:
CN122419380A
Publication Date:
2026-07-20
Applicant(s):
澳門大學; University of Macau
Inventor(s):
李海華；李家明；麥沛然；馬許願; Li Haihua; Li Jiaming; Mai Peiran; Rui Paulo da Silva Martins
Technology Field(s):
基本通訊流程; Basic communication processes
The present invention discloses a temperature-compensated quartz crystal oscillator and an implementation method thereof. An auxiliary amplifier is used to start the crystal oscillator and output a first clock signal, and a load capacitor array outputs a second clock signal based on the first clock signal. A primary delay-locked loop generates multiple delay signals and a control voltage signal according to the second clock signal. A pulse injection module injects energy into the crystal oscillator according to the delay signals. A digitization module and a lookup module sequentially convert the control voltage signal into a digital signal and a clock selection signal. A modulation module generates a modulation signal based on the delay signals and the clock selection signal. The load capacitor array then adjusts the capacitor connection time of the crystal oscillator according to the modulation signal. By improving the modulation method of the load capacitor array, the invention reduces Allan variance, and by reusing circuits and optimizing the conversion process of temperature information, it reduces area and power consumption. It can be widely applied in the technical field of crystal oscillators.
Publication No.:
CN122419380A
Publication Date:
2026-07-20
Applicant(s):
澳門大學; University of Macau
Inventor(s):
李海華；李家明；麥沛然；馬許願; Li Haihua; Li Jiaming; Mai Peiran; Rui Paulo da Silva Martins
Technology Field(s):
基本通訊流程; Basic communication processes
The present invention discloses a temperature-compensated quartz crystal oscillator and an implementation method thereof. An auxiliary amplifier is used to start the crystal oscillator and output a first clock signal, and a load capacitor array outputs a second clock signal based on the first clock signal. A primary delay-locked loop generates multiple delay signals and a control voltage signal according to the second clock signal. A pulse injection module injects energy into the crystal oscillator according to the delay signals. A digitization module and a lookup module sequentially convert the control voltage signal into a digital signal and a clock selection signal. A modulation module generates a modulation signal based on the delay signals and the clock selection signal. The load capacitor array then adjusts the capacitor connection time of the crystal oscillator according to the modulation signal. By improving the modulation method of the load capacitor array, the invention reduces Allan variance, and by reusing circuits and optimizing the conversion process of temperature information, it reduces area and power consumption. It can be widely applied in the technical field of crystal oscillators.
A fast lock loop and its control method
一種快速鎖定環路及其控制方法
Publication No.:
CN122419452A
Publication Date:
2026-07-20
Applicant(s):
澳門大學; University of Macau
Inventor(s):
李浩然；殷俊；麥沛然；馬許願; Li Haoran; Yin Jun; Mai Peiran; Rui Paulo da Silva Martins
Technology Field(s):
基本通訊流程、測量; Basic communication processes, Measurement
The present invention discloses a fast lock-in loop and its control method, comprising a phase reset circuit, a multi‑mode divider, a quantization noise compensation circuit, an integer phase‑locked loop, a time‑to‑digital converter, a digital calibration circuit, a digital filter, a digital‑to‑analog converter, and a voltage‑controlled oscillator. The outputs of the phase reset circuit and the quantization noise compensation circuit are connected to the multi‑mode divider. The output of the multi‑mode divider and the reference clock signal are connected to the integer phase‑locked loop and the time‑to‑digital converter. The output of the time‑to‑digital converter is connected to the digital calibration circuit and the quantization noise compensation circuit. The output of the digital calibration circuit is connected to the quantization noise compensation circuit. The output of the quantization noise compensation circuit is connected to the digital filter. The quantization noise compensation circuit is configured to compensate for quantization errors generated during fractional‑N phase locking. Embodiments of the present invention can realize fractional‑N phase locking, improve locking accuracy, and can be widely applied in the field of circuit technology.
Publication No.:
CN122419452A
Publication Date:
2026-07-20
Applicant(s):
澳門大學; University of Macau
Inventor(s):
李浩然；殷俊；麥沛然；馬許願; Li Haoran; Yin Jun; Mai Peiran; Rui Paulo da Silva Martins
Technology Field(s):
基本通訊流程、測量; Basic communication processes, Measurement
The present invention discloses a fast lock-in loop and its control method, comprising a phase reset circuit, a multi‑mode divider, a quantization noise compensation circuit, an integer phase‑locked loop, a time‑to‑digital converter, a digital calibration circuit, a digital filter, a digital‑to‑analog converter, and a voltage‑controlled oscillator. The outputs of the phase reset circuit and the quantization noise compensation circuit are connected to the multi‑mode divider. The output of the multi‑mode divider and the reference clock signal are connected to the integer phase‑locked loop and the time‑to‑digital converter. The output of the time‑to‑digital converter is connected to the digital calibration circuit and the quantization noise compensation circuit. The output of the digital calibration circuit is connected to the quantization noise compensation circuit. The output of the quantization noise compensation circuit is connected to the digital filter. The quantization noise compensation circuit is configured to compensate for quantization errors generated during fractional‑N phase locking. Embodiments of the present invention can realize fractional‑N phase locking, improve locking accuracy, and can be widely applied in the field of circuit technology.
A dynamic scheduling method and system for multi-dimensional resources in off-line mixed parts [Granted Patent]
一種多維資源在離線混部的動態排程方法及其系統 [授權專利]
Publication No.:
CN115454631B
Publication Date:
2026-07-20
Applicant(s):
中國科學院深圳先進技術研究院；澳門大學; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; University of Macau
Inventor(s):
葉可江；林鵬；須成忠; Ye Kejiang; Lin Peng; Xu Chengzhong
Technology Field(s):
電腦技術; Computer technology
The present invention relates to the technical field of offline resource scheduling, and in particular to a dynamic scheduling method and system for multidimensional resources in an offline mixed-deployment environment. In the present invention, upon submission of a new job, a screening process is first performed to filter out nodes that meet the requirements. Then, based on the variation in each node’s interference health value, each node performs dynamic resource adjustment and re‑migration of offline jobs. Next, the current resource monitoring indicators of each node are obtained and the historical monitoring data is maintained. At preset time intervals, the resource monitoring indicators of each node are continuously acquired, and the current interference health value of each node is thereby calculated. Finally, based on the interference health values of the nodes, a score is assigned to each node, and the node with the highest score is selected as the scheduling node, to which the new job is dispatched. By monitoring resource data indicators and adopting a strategy of dynamic resource adjustment after initial scheduling followed by re‑migration, the present invention ensures that the performance of online jobs is not affected in mixed‑deployment scenarios.
Publication No.:
CN115454631B
Publication Date:
2026-07-20
Applicant(s):
中國科學院深圳先進技術研究院；澳門大學; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; University of Macau
Inventor(s):
葉可江；林鵬；須成忠; Ye Kejiang; Lin Peng; Xu Chengzhong
Technology Field(s):
電腦技術; Computer technology
The present invention relates to the technical field of offline resource scheduling, and in particular to a dynamic scheduling method and system for multidimensional resources in an offline mixed-deployment environment. In the present invention, upon submission of a new job, a screening process is first performed to filter out nodes that meet the requirements. Then, based on the variation in each node’s interference health value, each node performs dynamic resource adjustment and re‑migration of offline jobs. Next, the current resource monitoring indicators of each node are obtained and the historical monitoring data is maintained. At preset time intervals, the resource monitoring indicators of each node are continuously acquired, and the current interference health value of each node is thereby calculated. Finally, based on the interference health values of the nodes, a score is assigned to each node, and the node with the highest score is selected as the scheduling node, to which the new job is dispatched. By monitoring resource data indicators and adopting a strategy of dynamic resource adjustment after initial scheduling followed by re‑migration, the present invention ensures that the performance of online jobs is not affected in mixed‑deployment scenarios.
A cooperative control method and device for power network and communication network [Granted Patent]
一種電力網路與通訊網路協同調控方法和裝置 [授權專利]
Publication No.:
CN120511675B
Publication Date:
2026-07-20
Applicant(s):
澳門大學; University of Macau
Inventor(s):
惠紅勳；馬麗雅；宋永華; Hui Hongxun; Ma Liya; Song Yonghua
Technology Field(s):
電機、設備、能源; Electrical machinery, apparatus, energy
The present invention discloses a method and device for coordinated control between a power network and a communication network. The method includes: acquiring flexible resource data information; calculating the control data value of the flexible resources based on the flexible resource data information; calculating the output of an equivalent model of the coupled power and communication network according to the composition structure of an equivalent power network; constructing a set of operating constraints for the power network; and, based on the control data value of the flexible resources, the output of the equivalent model of the coupled power and communication network, and the set of operating constraints of the power network, constructing a coordinated control objective function, where the objective of the coordinated control objective function is to maximize the net benefit of power regulation and the net benefit of data communication. Coordinated control of the coupled network is then performed according to the coordinated control objective function. The present invention achieves network-wide coordinated control and improves the benefits of such coordinated control. The present invention can be widely applied in the technical field of dispatching flexible power resources.
Publication No.:
CN120511675B
Publication Date:
2026-07-20
Applicant(s):
澳門大學; University of Macau
Inventor(s):
惠紅勳；馬麗雅；宋永華; Hui Hongxun; Ma Liya; Song Yonghua
Technology Field(s):
電機、設備、能源; Electrical machinery, apparatus, energy
The present invention discloses a method and device for coordinated control between a power network and a communication network. The method includes: acquiring flexible resource data information; calculating the control data value of the flexible resources based on the flexible resource data information; calculating the output of an equivalent model of the coupled power and communication network according to the composition structure of an equivalent power network; constructing a set of operating constraints for the power network; and, based on the control data value of the flexible resources, the output of the equivalent model of the coupled power and communication network, and the set of operating constraints of the power network, constructing a coordinated control objective function, where the objective of the coordinated control objective function is to maximize the net benefit of power regulation and the net benefit of data communication. Coordinated control of the coupled network is then performed according to the coordinated control objective function. The present invention achieves network-wide coordinated control and improves the benefits of such coordinated control. The present invention can be widely applied in the technical field of dispatching flexible power resources.
A sensor interface including discrete-time amplifier
包括離散時間放大器的感測器介面
Publication No.:
CN122394508A
Publication Date:
2026-07-20
Applicant(s):
澳門大學; University of Macau
Inventor(s):
胡可；吳江潮；羅文基; Hu Ke; Wu Jiangchao; Luo Wenji
Technology Field(s):
基本通訊流程; Basic communication processes
This application discloses a sensor interface including a discrete-time amplifier, belonging to the technical field of sensor interface circuits. The sensor interface comprises: a first-stage amplification circuit, a second-stage amplification circuit, a noise cancellation network including multiple noise storage capacitors, and a buffer circuit. The second-stage amplification circuit is connected to the corresponding port of the first-stage amplification circuit, and the buffer circuit is connected to the corresponding port of the second-stage amplification circuit through the noise storage capacitors. The sensor interface receives a differential input voltage through the first-stage amplification circuit to generate a first differential signal. After being amplified by the second-stage amplification circuit, the signal is transferred via the noise storage capacitors to the buffer circuit, which outputs a differential output voltage. In this way, the interface effectively amplifies the signal while cancelling sampling noise, thereby breaking the dependence of the discrete-time amplifier’s noise on the switching frequency and capacitor size, and at the same time reducing the switching frequency and capacitor size. This optimizes the trade-off between current and noise efficiency factor, as well as between power consumption and power efficiency factor.
Publication No.:
CN122394508A
Publication Date:
2026-07-20
Applicant(s):
澳門大學; University of Macau
Inventor(s):
胡可；吳江潮；羅文基; Hu Ke; Wu Jiangchao; Luo Wenji
Technology Field(s):
基本通訊流程; Basic communication processes
This application discloses a sensor interface including a discrete-time amplifier, belonging to the technical field of sensor interface circuits. The sensor interface comprises: a first-stage amplification circuit, a second-stage amplification circuit, a noise cancellation network including multiple noise storage capacitors, and a buffer circuit. The second-stage amplification circuit is connected to the corresponding port of the first-stage amplification circuit, and the buffer circuit is connected to the corresponding port of the second-stage amplification circuit through the noise storage capacitors. The sensor interface receives a differential input voltage through the first-stage amplification circuit to generate a first differential signal. After being amplified by the second-stage amplification circuit, the signal is transferred via the noise storage capacitors to the buffer circuit, which outputs a differential output voltage. In this way, the interface effectively amplifies the signal while cancelling sampling noise, thereby breaking the dependence of the discrete-time amplifier’s noise on the switching frequency and capacitor size, and at the same time reducing the switching frequency and capacitor size. This optimizes the trade-off between current and noise efficiency factor, as well as between power consumption and power efficiency factor.